My brother and I take these. They do work, but our pH is not yet 7 as it has to be. But I think that's normal if you follow a detox program. At least my pH is never lower as 6 anymore. Before it was 5 or less. Sometimes I take 1 alkalizer capsule extra with these and then my pH is oke. So this one (enzymedica)is maybe a a little expensive. You can also use an alalizer(powder for) they are cheaper. I use them both. But I don't overdose.